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Cell size is a determinant of stem cell potential during aging.

ABSTRACT: Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential under conditions causing stem cell exhaustion. Last, we show that murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging.

SUBMITTER: Lengefeld J

PROVIDER: S-EPMC8589318 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Cell size is a determinant of stem cell potential during aging.

Lengefeld Jette J Cheng Chia-Wei CW Maretich Pema P Blair Marguerite M Hagen Hannah H McReynolds Melanie R MR Sullivan Emily E Majors Kyra K Roberts Christina C Kang Joon Ho JH Steiner Joachim D JD Miettinen Teemu P TP Manalis Scott R SR Antebi Adam A Morrison Sean J SJ Lees Jacqueline A JA Boyer Laurie A LA Yilmaz Ömer H ÖH Amon Angelika A

Science advances 20211112 46

Stem cells are remarkably small. Whether small size is important for stem cell function is unknown. We find that hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferation and was accompanied by altered metabolism. Preventing HSC enlargement or reducing large HSCs in size averts the loss of stem cell potential under conditions causing stem cell exhaustion. Last, we show that murine and human ...[more]

PMID: 34767451

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