Highly expressed of SERPINA3 indicated poor prognosis and involved in immune suppression in glioma.

ABSTRACT:

Introduction

The prognosis of patients with glioma is dismal. It has been reported that Serpin peptidase inhibitor clade A member 3 (SERPINA3) is associated with the mobility and invasion of tumor cells. Our study was designed to explore the value of SERPINA3 messenger RNA (mRNA) expression in the biological process, prognosis, and immune significance in glioma.

Methods

We analyzed the biological functions of SERPINA3 through data from the Chinese Glioma Genome Atlas databases. Differentially expressed genes and enrichment analysis were performed and correlations between SERPINA3 expression and immune cell infiltration were analyzed. Further, we validated the expression and the survival prediction role of SERPINA3 by using tissue microarrays and RNAscope in situ hybridizatio

SUBMITTER: Yuan Q 

PROVIDER: S-EPMC8589354 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature