Impaired T helper cell responses in human immunodeficiency virus-exposed uninfected newborns.

ABSTRACT:

Introduction

HIV-exposed uninfected (HEU) newborns suffer from higher risks of opportunistic infections during the first months of life compared to HIV-unexposed uninfected (HUU) newborns. Alterations in thymic mass, amounts of T helper (Th) cells, T-cell receptor diversity, and activation markers have been found in HEU newborns, suggesting alterations in T cell ontogeny and differentiation. However, little is known about the ability of these cells to produce specialized Th responses from CD4⁺ T cells.

Method

To characterize the Th cell profile, we evaluated the frequency of Th₁ (CD183⁺ CD194^- CD196^- /CXCR3⁺ CCR4^- CCR6^- ), Th₂ (CD183^- CD194⁺ CD196^-

SUBMITTER: Brito-Perez Y 

PROVIDER: S-EPMC8589403 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature