Semi- and fully synthetic carbohydrate vaccines against pathogenic bacteria: recent developments.

ABSTRACT: The importance of vaccine-induced protection was repeatedly demonstrated over the last three decades and emphasized during the recent COVID-19 pandemic as the safest and most effective way of preventing infectious diseases. Vaccines have controlled, and in some cases, eradicated global viral and bacterial infections with high efficiency and at a relatively low cost. Carbohydrates form the capsular sugar coat that surrounds the outer surface of human pathogenic bacteria. Specific surface-exposed bacterial carbohydrates serve as potent vaccine targets that broadened our toolbox against bacterial infections. Since first approved for commercial use, antibacterial carbohydrate-based vaccines mostly rely on inherently complex and heterogenous naturally derived polysaccharides, challenging to obt

SUBMITTER: Zaslona ME 

PROVIDER: S-EPMC8589429 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature