Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells.

ABSTRACT: The global health burden due to sepsis and the associated cytokine storm is substantial. While early intervention has improved survival during the cytokine storm, those that survive can enter a state of chronic immunoparalysis defined by transient lymphopenia and functional deficits of surviving cells. Memory CD8 T cells provide rapid cytolysis and cytokine production following re-encounter with their cognate antigen to promote long-term immunity, and CD8 T cell impairment due to sepsis can pre-dispose individuals to re-infection. While the acute influence of sepsis on memory CD8 T cells has been characterized, if and to what extent pre-existing memory CD8 T cells recover remains unknown. Here, we observed that central memory CD8 T cells (T_CM) from septic patients proliferate mo

SUBMITTER: Jensen IJ 

PROVIDER: S-EPMC8589447 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature