Association of maternal pre-pregnancy BMI and breastfeeding with NAFLD in young adults: a parental negative control study.

ABSTRACT:

Background

The importance of the maternal-infant dyad in the genesis of nonalcoholic fatty liver disease (NAFLD) is of increasing interest. The Avon Longitudinal Study of Parents and Children (ALSPAC) showed that at age 24, 1 in 5 had NAFLD measured by transient elastography and controlled attenuation parameter (CAP). Our aim was to investigate the association between breastfeeding duration and maternal pre-pregnancy BMI on offspring NAFLD in young adulthood.

Methods

4021 participants attended clinic for FibroScan and CAP measurement using Echosens 502 Touch®. 440 participants with Alcohol Use Disorders were excluded. Offspring of 100 non-singleton pregnancies were excluded. 2961 valid CAP measurements for NAFLD were analysed. Exposures of interest were breastfeeding of any

SUBMITTER: Abeysekera KW 

PROVIDER: S-EPMC8589711 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature