Whole-body MRI versus an [¹⁸F]FDG-PET/CT-based reference standard for early response assessment and restaging of paediatric Hodgkin's lymphoma: a prospective multicentre study.

ABSTRACT:

Objectives

To compare WB-MRI with an [¹⁸F]FDG-PET/CT-based reference for early response assessment and restaging in children with Hodgkin's lymphoma (HL).

Methods

Fifty-one children (ages 10-17) with HL were included in this prospective, multicentre study. All participants underwent WB-MRI and [¹⁸F]FDG-PET/CT at early response assessment. Thirteen of the 51 patients also underwent both WB-MRI and [¹⁸F]FDG-PET/CT at restaging. Two radiologists independently evaluated all WB-MR images in two separate readings: without and with DWI. The [¹⁸F]FDG-PET/CT examinations were evaluated by a nuclear medicine physician. An expert panel assessed all discrepancies between WB-MRI and [¹⁸F]FDG-PET/CT to derive the [¹⁸F]FDG-P

SUBMITTER: Spijkers S 

PROVIDER: S-EPMC8589741 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature