Clinical Significance of Alpha-Fetoprotein in Alpha-Fetoprotein Negative Hepatocellular Carcinoma Underwent Curative Resection.

ABSTRACT:

Background

The clinical value of alpha-fetoprotein (AFP) in patients with AFP-negative (< 20 ng/ml) hepatocellular carcinoma (HCC) who underwent curative resection remained controversial.

Aims

To investigate clinical relevance and prognostic effect of preoperative serum AFP level in this subgroup.

Methods

A total of 1879 patients with AFP-negative HCC who underwent curative resection were included in the study. Overall survival (OS) and disease-free survival (DFS) rate were displayed by Kaplan-Meier method and compared by log-rank test. Multivariate cox proportional hazard regression analysis was used to identify the independent prognostic factors. The prognostic predictive performance was analyzed by time-dependent areas under receiver operating characteristic curve

SUBMITTER: Lin K 

PROVIDER: S-EPMC8589766 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature