Pharmacokinetic and molecular docking studies to design antimalarial compounds targeting Actin I.

ABSTRACT:

Objective

Malaria is an ancient disease that still causes more than 200 million of cases 7 with high mortality globally. Identification of new drug targets and development of novel antimalarial drugs with unique mode of action encounter the drug resistance and reduce the mortality by Plasmodium parasites. Actin protein is one of the key proteins in Plasmodium falciparum playing multifarious important roles including transport, cell motility, cell division, and shape determination. This study investigated Actin I as a drug target, in silico screening of diverse molecules through molecular docking was considered. Further, pharmacokinetic parameters of the selected molecules from the docking and interaction studies were planned to propose the lead molecules.b.

SUBMITTER: Guleria V 

PROVIDER: S-EPMC8589829 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature