Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults.

ABSTRACT:

Introduction

Neurite orientation dispersion and density imaging (NODDI), a multi-compartment diffusion-weighted imaging (DWI) model, may be useful for detecting early cortical microstructural alterations in Alzheimer's disease prior to cognitive impairment.

Methods

Using neuroimaging (NODDI and T1-weighted magnetic resonance imaging [MRI]) and cerebrospinal fluid (CSF) biomarker data (measured using Elecsys® CSF immunoassays) from 219 cognitively unimpaired participants, we tested the main and interactive effects of CSF amyloid beta (Aβ)₄₂ /Aβ₄₀ and phosphorylated tau (p-tau) on cortical NODDI metrics and cortical thickness, controlling for age, sex, and apolipoprotein E ε4.

Results

We observed a significant CSF Aβ₄₂ /Aβ₄₀ ×

SUBMITTER: Vogt NM 

PROVIDER: S-EPMC8589921 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature