EANM dosimetry committee series on standard operational procedures: a unified methodology for ^99mTc-MAA pre- and ⁹⁰Y peri-therapy dosimetry in liver radioembolization with ⁹⁰Y microspheres.

ABSTRACT: The aim of this standard operational procedure is to standardize the methodology employed for the evaluation of pre- and post-treatment absorbed dose calculations in ⁹⁰Y microsphere liver radioembolization. Basic assumptions include the permanent trapping of microspheres, the local energy deposition method for voxel dosimetry, and the patient-relative calibration method for activity quantification.The identity of ^99mTc albumin macro-aggregates (MAA) and ⁹⁰Y microsphere biodistribution is also assumed. The large observed discrepancies in some patients between ^99mTc-MAA predictions and actual ⁹⁰Y microsphere distributions for lesions is discussed. Absorbed dose predictions to whole non-tumoural liver are considered more reliable and the

SUBMITTER: Chiesa C 

PROVIDER: S-EPMC8589932 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature