Aging impairs human bone marrow function and cardiac repair following myocardial infarction in a humanized chimeric mouse.

ABSTRACT: Ventricular remodeling following myocardial infarction (MI) is a major cause of heart failure, a condition prevalent in older individuals. Following MI, immune cells are mobilized to the myocardium from peripheral lymphoid organs and play an active role in orchestrating repair. While the effect of aging on mouse bone marrow (BM) has been studied, less is known about how aging affects human BM cells and their ability to regulate repair processes. In this study, we investigate the effect aging has on human BM cell responses post-MI using a humanized chimeric mouse model. BM samples were collected from middle aged (mean age 56.4 ± 0.97) and old (mean age 72.7 ± 0.59) patients undergoing cardiac surgery, CD34^+/- cells were isolated, and NOD-scid-IL2rγ^null (NSG) mice were

SUBMITTER: Marvasti TB 

PROVIDER: S-EPMC8590094 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature