Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B.

ABSTRACT: A hallmark of advanced maternal age is a significant increase in meiotic chromosome segregation errors, resulting in early miscarriages and congenital disorders. These errors most frequently occur during meiosis I (MI). The spindle assembly checkpoint (SAC) prevents chromosome segregation errors by arresting the cell cycle until proper chromosome alignment is achieved. Unlike in mitosis, the SAC in oocytes is desensitized, allowing chromosome segregation in the presence of improperly aligned chromosomes. Whether SAC integrity further deteriorates with advancing maternal age, and if this decline contributes to increased segregation errors remains a fundamental question. In somatic cells, activation of the SAC depends upon Aurora kinase B (AURKB), which functions to monitor kinetochore-micro

SUBMITTER: Blengini CS 

PROVIDER: S-EPMC8590096 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature