Innate immune remodeling by short-term intensive fasting.

ABSTRACT: Previous studies have shown that long-term light or moderate fasting such as intermittent fasting can improve health and prolong lifespan. However, in humans short-term intensive fasting, a complete water-only fasting has little been studied. Here, we used multi-omics tools to evaluate the impact of short-term intensive fasting on immune function by comparison of the CD45⁺ leukocytes from the fasting subjects before and after 72-h fasting. Transcriptomic and proteomic profiling of CD45⁺ leukocytes revealed extensive expression changes, marked by higher gene upregulation than downregulation after fasting. Functional enrichment of differentially expressed genes and proteins exposed several pathways critical to metabolic and immune cell functions. Specifically, short-ter

SUBMITTER: Qian J 

PROVIDER: S-EPMC8590100 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature