CosinoRmixedeffects: an R package for mixed-effects cosinor models.

ABSTRACT:

Background

Wearable devices enable monitoring and measurement of physiological parameters over a 24-h period, and some of which exhibit circadian rhythm characteristics. However, the currently available R package cosinor could only analyze daily cross-sectional data and compare the parameters between groups with two levels. To evaluate longitudinal changes in the circadian patterns, we need to extend the model to a mixed-effect model framework, allowing for random effects and interaction between COSINOR parameters and time-varying covariates.

Results

We developed the cosinoRmixedeffects R package for modelling longitudinal periodic data using mixed-effects cosinor models. The model allows for covariates and interactions with the non-linear parameters MESOR, amplitude, and ac

SUBMITTER: Hou R 

PROVIDER: S-EPMC8590130 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature