Association Between Androgen Deprivation Therapy and Mortality Among Patients With Prostate Cancer and COVID-19.

ABSTRACT:

Importance

Androgen deprivation therapy (ADT) has been theorized to decrease the severity of SARS-CoV-2 infection in patients with prostate cancer owing to a potential decrease in the tissue-based expression of the SARS-CoV-2 coreceptor transmembrane protease, serine 2 (TMPRSS2).

Objective

To examine whether ADT is associated with a decreased rate of 30-day mortality from SARS-CoV-2 infection among patients with prostate cancer.

Design, setting, and participants

This cohort study analyzed patient data recorded in the COVID-19 and Cancer Consortium registry between March 17, 2020, and February 11, 2021. The consortium maintains a centralized multi-institution registry of patients with a current or past diagnosis of cancer who developed COVID-19. Data were collected and

SUBMITTER: Schmidt AL 

PROVIDER: S-EPMC8590166 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature