Increased AT₁ receptor expression mediates vasoconstriction leading to hypertension in Snx1^-/- mice.

ABSTRACT: Angiotensin II type 1 receptor (AT₁R) is a vital therapeutic target for hypertension. Sorting nexin 1 (SNX1) participates in the sorting and trafficking of the renal dopamine D₅ receptor, while angiotensin and dopamine are counterregulatory factors in the regulation of blood pressure. The effect of SNX1 on AT₁R is not known. We hypothesized that SNX1, through arterial AT₁R sorting and trafficking, is involved in blood pressure regulation. CRISPR/Cas9 system-generated SNX1^-/- mice showed dramatic elevations in blood pressure compared to their wild-type littermates. The angiotensin II-mediated contractile reactivity of the mesenteric arteries and AT₁R expression in the aortas were also increased. Moreover, immunofluorescence a

SUBMITTER: Liu C 

PROVIDER: S-EPMC8590203 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature