NAP1L1 interacts with hepatoma-derived growth factor to recruit c-Jun inducing breast cancer growth.

ABSTRACT:

Background

Breast cancer is a common cancer among women in the world. However, its pathogenesis is still to be determined. The role and molecular mechanism of Nucleosome Assembly Protein 1 Like 1 (NAP1L1) in breast cancer have not been reported. Elucidation of molecular mechanism might provide a novel therapeutic target for breast cancer treatment.

Methods

A bioinformatics analysis was conducted to determine the differential expression of NAP1L1 in breast cancer and find the potential biomarker that interacts with NAP1L1 and hepatoma-derived growth factor (HDGF). The expression of NAP1L1 in tissues was detected by using immunohistochemistry. Breast cancer cells were transfected with the corresponding lentiviral particles and siRNA. The efficiency of transfection was measured

SUBMITTER: Liu S 

PROVIDER: S-EPMC8590370 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature