Pleiotropy between language impairment and broader behavioral disorders-an investigation of both common and rare genetic variants.

ABSTRACT:

Background

Language plays a major role in human behavior. For this reason, neurodevelopmental and psychiatric disorders in which linguistic ability is impaired could have a big impact on the individual's social interaction and general wellbeing. Such disorders tend to have a strong genetic component, but most past studies examined mostly the linguistic overlaps across these disorders; investigations into their genetic overlaps are limited. The aim of this study was to assess the potential genetic overlap between language impairment and broader behavioral disorders employing methods capturing both common and rare genetic variants.

Methods

We employ polygenic risk scores (PRS) trained on specific language impairment (SLI) to evaluate genetic overlap across several disorders in

SUBMITTER: Nudel R 

PROVIDER: S-EPMC8590378 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature