Multidimensional Analysis of the Role of Charged Multivesicular Body Protein 7 in Pan-Cancer.

ABSTRACT:

Background

Charged multivesicular body protein 7 is briefly referred to as CHMP7, and it plays a significant role in the endosomal sorting pathway. CHMP7 can form a complex with ESCRTIII to jointly complete the process of contraction, shear bud neck and final membrane shedding.

Methods

TCGA, GEO and CPTAC were chosen for the analysis of the role of CHMP7 in pan-cancer. Role of CHMP7 in pan-cancer was analyzed using R software and tools such as TIMER, GEPIA, UALCAN, String and DiseaseMeth. It includes differential expression analysis of CHMP7, survival analysis, genetic variation analysis, DNA methylation analysis, post-translationally modified protein phosphorylation analysis and functional enrichment analysis.

Results

CHMP7 presents low expression in the majority of

SUBMITTER: Guo Y 

PROVIDER: S-EPMC8590578 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature