Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression.

ABSTRACT: HER2-positive breast cancers may lose HER2 expression in recurrences and metastases. In this work, we studied cell lines derived from two transgenic mammary tumors driven by human HER2 that showed different dynamics of HER2 status. MamBo89HER2^stable cell line displayed high and stable HER2 expression, which was maintained upon in vivo passages, whereas MamBo43HER2^labile cell line gave rise to HER2-negative tumors from which MamBo38HER2^loss cell line was derived. Both low-density seeding and in vitro trastuzumab treatment of MamBo43HER2^labile cells induced the loss of HER2 expression. MamBo38HER2^loss cells showed a spindle-like morphology, high stemness and acquired in vivo malignancy. A comprehensive molecular profile confirmed the los

SUBMITTER: Giusti V 

PROVIDER: S-EPMC8590694 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature