Effectiveness and safety of SARS-CoV-2 vaccine in real-world studies: a systematic review and meta-analysis.

ABSTRACT:

Background

To date, coronavirus disease 2019 (COVID-19) becomes increasingly fierce due to the emergence of variants. Rapid herd immunity through vaccination is needed to block the mutation and prevent the emergence of variants that can completely escape the immune surveillance. We aimed to systematically evaluate the effectiveness and safety of COVID-19 vaccines in the real world and to establish a reliable evidence-based basis for the actual protective effect of the COVID-19 vaccines, especially in the ensuing waves of infections dominated by variants.

Methods

We searched PubMed, Embase and Web of Science from inception to July 22, 2021. Observational studies that examined the effectiveness and safety of SARS-CoV-2 vaccines among people vaccinated were included. Random-eff

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8590867 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature