Responsivity and Reproducibility of Sputum Inflammatory Biomarkers During COPD Exacerbation and Stable Phases - A Pilot Study.

ABSTRACT:

Introduction

There is a great interest to identify airway biomarkers to evaluate the potential and efficacy of anti-inflammatory therapeutic interventions. In this pilot study, we compared cytokine mRNA and protein levels of IL-6, IL-8, CCL2, CCL4, and TNF-α, as well as LTB-4 expression regarding their reproducibility and responsivity in induced sputum in COPD patients.

Methods

We recruited a cohort of 17 patients with a moderate COPD exacerbation, necessitating antibiotics and/or oral corticosteroids. Patients were followed for two consecutive stable phase visits. Cytokine mRNA and protein levels were measured in induced sputum samples.

Results

IL-6 and CCL4 protein levels decreased from exacerbation to stable phase, whereas their mRNA expression showed the same tren

SUBMITTER: Ditz B 

PROVIDER: S-EPMC8590961 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature