Chronic mineral oil administration increases hepatic inflammation in wild type mice compared to lipocalin 2 null mice.

ABSTRACT: Lipocalin 2 (LCN2), an acute-phase protein produced during acute liver injury, plays an important role in the innate immune response against bacterial infection via iron scavenging. LCN2 further influences neutrophil development and physiology leading to increased inflammatory responses. We investigated the roles of LCN2 in chronic inflammation and fibrosis, using repeated carbon tetrachloride (CCl₄) in mineral-oil injection. Surprisingly, mice treated with the mineral oil vehicle alone showed liver inflammation, evidenced by neutrophil and monocyte-macrophage infiltration. Fluorescence-activated cell sorting (FACS) of isolated liver leukocytes showed significantly high CD45⁺ leukocyte concentrations in CCl₄ mice, but no difference of Ly6G⁺ neutr

SUBMITTER: Borkham-Kamphorst E 

PROVIDER: S-EPMC8590977 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature