Insights from patients screened but not randomised in the HYPERION trial.

ABSTRACT:

Background

Few data are available about outcomes of patients screened for, but not enrolled in, randomised clinical trials.

Methods

We retrospectively reviewed patients who had non-inclusion criteria for the HYPERION trial comparing 33 °C to 37 °C in patients comatose after cardiac arrest in non-shockable rhythm, due to any cause. A good neurological outcome was defined as a day-90 Cerebral Performance Category score of 1 or 2.

Results

Of the 1144 patients with non-inclusion criteria, 1130 had day-90 information and, among these, 158 (14%) had good functional outcomes, compared to 7.9% overall in the HYPERION trial (10.2% with and 5.7% without hypothermia). Considerable centre-to-centre variability was found in the proportion of non-included patients who received hypo

SUBMITTER: Lascarrou JB 

PROVIDER: S-EPMC8590986 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature