Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency.

ABSTRACT: There is ample evidence supporting a role for angiotensin II type 2 receptor (AT₂R) in counterbalancing the effects of angiotensin II (ang II) through the angiotensin II type 1 receptor by promoting vasodilation and having anti-inflammatory effects. Elastin insufficiency in both humans and mice results in large artery stiffness and systolic hypertension. Unexpectedly, mesenteric arteries from elastin insufficient (Eln ^+/-) mice were shown to have significant vasoconstriction to AT₂R agonism in vitro suggesting that AT₂R may have vasoconstrictor effects in elastin insufficiency. Given the potential promise for the use of AT₂R agonists clinically, the goal of this study was to determine whether AT₂R has vasoconst

SUBMITTER: Lin M 

PROVIDER: S-EPMC8591102 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature