Evaluation Expression of miR-146a and miR-155 in Non-Small-Cell Lung Cancer Patients.

ABSTRACT:

Background

Non-small-cell lung cancer (NSCLC) is the major type of lung cancer. MicroRNAs (miRNAs) are novel markers and targets in cancer therapy and can act as both tumor suppressors and oncogenes and affect immune function. The aim of this study was to investigate the expression of miR146a and miR155 in linked to blood immune cell phenotypes and serum cytokines in NSCLC patients.

Methods

Thirty-three NSCLC patients and 30 healthy subjects were enrolled in this study. The allele frequencies of potential DNA polymorphisms were studied using polymerase chain reaction (PCR)-restriction fragment length polymorphism (PCR-RFLP) analysis in peripheral blood samples. Quantitative reverse transcription PCR (qRT-PCR) was used to measure the expression of miR-146a and miR-155 in peri

SUBMITTER: Dezfuli NK 

PROVIDER: S-EPMC8591170 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature