DC-SIGN Mediates the Interaction Between Neutrophils and Leishmania amazonensis-Infected Dendritic Cells to Promote DC Maturation and Parasite Elimination.

ABSTRACT:

Background

Leishmaniasis is a neglected arthropod-borne disease that affects millions of people worldwide. Successful Leishmania infections require the mitigation of immune cell functions leading to parasite survival and proliferation. A large body of evidence highlights the involvement of neutrophils (PMNs) and dendritic cells (DCs) in the establishment of immunological responses against these parasites. However, few studies, contemplate to what extent these cells interact synergistically to constrain Leishmania infection.

Objective

We sought to investigate how PMNs and infected DCs interact in an in vitro model of Leishmania amazonensis infection.

Material and methods

Briefly, human PMNs and DCs were purified from the peripheral blood of

SUBMITTER: Tiburcio R 

PROVIDER: S-EPMC8591281 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature