Identifying tumorigenic non-coding mutations through altered cis-regulation.
Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Z
PROVIDER: S-EPMC8591365 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Identifying tumorigenic non-coding mutations through altered <i>cis</i>-regulation.
Cheng Zhongshan Z Vermeulen Michael M Rollins-Green Micheal M Babak Tomas T DeVeale Brian B
STAR protocols 20211108 4
Identification of non-coding mutations driving tumorigenesis requires alternative approaches to coding mutations. Enriched associations between mutated regulatory elements and altered cis-regulation in tumors are a promising approach to stratify candidate non-coding driver mutations. Here we provide a bioinformatics pipeline to mine data from the Cancer Genomic Commons (GDC) for such associations. The pipeline integrates RNA and whole-genome sequencing with genotyping data to reveal putative non ...[more]
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