Physiological effects and subjective tolerability of prone positioning in COVID-19 and healthy hypoxic challenge.

ABSTRACT:

Background

Prone positioning has a beneficial role in coronavirus disease 2019 (COVID-19) patients receiving ventilation but lacks evidence in awake non-ventilated patients, with most studies being retrospective, lacking control populations and information on subjective tolerability.

Methods

We conducted a prospective, single-centre study of prone positioning in awake non-ventilated patients with COVID-19 and non-COVID-19 pneumonia. The primary outcome was change in peripheral oxygenation in prone versus supine position. Secondary outcomes assessed effects on end-tidal CO₂, respiratory rate, heart rate and subjective symptoms. We also recruited healthy volunteers to undergo proning during hypoxic challenge.

Results

238 hospitalised patients with pneu

SUBMITTER: Jha A 

PROVIDER: S-EPMC8591389 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature