Gas embolism under standard versus low pneumoperitoneum pressure during laparoscopic liver resection (GASES): study protocol for a randomized controlled trial.

ABSTRACT:

Background

Gas embolism induced by CO₂ pneumoperitoneum is commonly identified as a risk factor for morbidity, especially cardiopulmonary morbidity, after laparoscopic liver resection (LLR) in adults. Increasing pneumoperitoneum pressure (PP) contributes to gas accumulation following laparoscopy. However, few studies have examined the effects of PP in the context of LLR. In LLR, the PP-central venous pressure (CVP) gradient is increased due to hepatic vein rupture, hepatic sinusoid exposure, and low CVP management, which together increase the risk of CO₂ embolization. The aim of this study is to primarily determine the role of low PP (10 mmHg) on the incidence of severe gas embolism.

Methods

Adult participants (n = 140) undergoing elective LLR will be a

SUBMITTER: Jin D 

PROVIDER: S-EPMC8591437 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature