Non-invasive visual evoked potentials under sevoflurane versus ketamine-xylazine in rats.

ABSTRACT:

Background

Visual Evoked Potential (VEP) quantifies electrical signals produced in visual cortex in response to visual stimuli. VEP elicited by light flashes is a useful biomarker to evaluate visual function in preclinical models and it can be recorded in awake or anaesthetised state. Different types of anaesthesia influence VEP properties, such as latency, which measures the propagation speed along nerve fibers, and amplitude that quantifies the power of electrical signal.

Aim

The goal of this work is to compare VEPs elicited in Dark Agouti rats under two types of anaesthesia: volatile sevoflurane or injectable ketamine-xylazine.

Methods

VEP latency, amplitude, signal-to-noise ratio and recording duration were measured in Dark Agouti rats randomly assigned to two gro

SUBMITTER: Castoldi V 

PROVIDER: S-EPMC8591496 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature