MARCO⁺ lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination.

ABSTRACT: Viremia in the vertebrate host is a major determinant of arboviral reservoir competency, transmission efficiency, and disease severity. However, immune mechanisms that control arboviral viremia are poorly defined. Here, we identify critical roles for the scavenger receptor MARCO in controlling viremia during arthritogenic alphavirus infections in mice. Following subcutaneous inoculation, arthritogenic alphavirus particles drain via the lymph and are rapidly captured by MARCO+ lymphatic endothelial cells (LECs) in the draining lymph node (dLN), limiting viral spread to the bloodstream. Upon reaching the bloodstream, alphavirus particles are cleared from the circulation by MARCO-expressing Kupffer cells in the liver, limiting viremia and further viral dissemination. MARCO-mediated accumulati

SUBMITTER: Carpentier KS 

PROVIDER: S-EPMC8591538 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature