The association between heart failure and incident cancer in women: an analysis of the Women's Health Initiative.

ABSTRACT:

Aims

There is conflicting evidence whether heart failure (HF) is a risk factor for incident cancer. Despite population-based cohorts demonstrating this association, an analysis of the Physician's Health Study found no association in a cohort of mostly healthy males. We investigated the association of HF with incident cancer among a large cohort of post-menopausal women.

Methods and results

A prospective cohort study of 146 817 post-menopausal women age 50 to 79 years enrolled in the Women's Health Initiative from 1993-1998, and followed through 2015. The primary exposure was adjudicated incident HF diagnosis, including preserved and reduced ejection fraction in a sub-cohort. The primary outcome was adjudicated incident total and site-specific cancers. Hazard ratios were calc

SUBMITTER: Leedy DJ 

PROVIDER: S-EPMC8591611 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature