Clinicopathological and Prognostic Significance of PRMT5 in Cancers: A System Review and Meta-Analysis.

ABSTRACT:

Purpose

Since protein arginine methyltransferase 5 (PRMT5) is abnormally expressed in various tumors, in this study we aim to assess the association between PRMT5 and clinicopathological and prognostic features.

Methods

Electronic databases including PubMed, Web of Science, Scopus, ScienceDirect, and the Cochrane Library were searched until July 25, 2021. The critical appraisal of the eligible studies was performed using the Newcastle-Ottawa Quality Assessment Scale. Pooled hazard ratios (HR) and pooled odds ratios (OR) were calculated to assess the effect. Engauge Digitizer version 12.1, STATA version 15.1, and R version 4.0.5 were used to obtain and analysis the data.

Results

A total of 32 original studies covering 15,583 patients were included. In our data, it indi

SUBMITTER: Liang Z 

PROVIDER: S-EPMC8591649 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature