Ontology highlight
ABSTRACT:
SUBMITTER: Fritschi CJ
PROVIDER: S-EPMC8591726 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Fritschi Christopher J CJ Liang Shuaiyi S Mohammadi Mohammadjavad M Anang Saumya S Moraca Francesca F Chen Junhua J Madani Navid N Sodroski Joseph G JG Abrams Cameron F CF Hendrickson Wayne A WA Smith Amos B AB
ACS medicinal chemistry letters 20211029 11
The design and synthesis of butyl chain derivatives at the indane ring 3-position of our lead CD4-mimetic compound BNM-III-170 that inhibits human immunodeficiency virus (HIV-1) infection are reported. Optimization efforts were guided by crystallographic and computational analysis of the small-molecule ligands of the Phe43 cavity of the envelope glycoprotein gp120. Biological evaluation of <b>11</b>-<b>21</b> revealed that members of this series of CD4-mimetic compounds are able to inhibit HIV-1 ...[more]