Hyperoxia during extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest is associated with severe circulatory failure and increased mortality.

ABSTRACT:

Background

High levels of arterial oxygen pressures (PaO₂) have been associated with increased mortality in extracorporeal cardiopulmonary resuscitation (ECPR), but there is limited information regarding possible mechanisms linking hyperoxia and death in this setting, notably with respect to its hemodynamic consequences. We aimed therefore at evaluating a possible association between PaO₂, circulatory failure and death during ECPR.

Methods

We retrospectively analyzed 44 consecutive cardiac arrest (CA) patients treated with ECPR to determine the association between the mean PaO₂ over the first 24 h, arterial blood pressure, vasopressor and intravenous fluid therapies, mortality, and cause of deaths.

Results

Eleven patients (25%) survive

SUBMITTER: Bonnemain J 

PROVIDER: S-EPMC8591834 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature