Role of epidemiology in risk assessment: a case study of five ortho-phthalates.

ABSTRACT:

Background

The association between environmental chemical exposures and chronic diseases is of increasing concern. Chemical risk assessment relies heavily on pre-market toxicity testing to identify safe levels of exposure, often known as reference doses (RfD), expected to be protective of human health. Although some RfDs have been reassessed in light of new hazard information, it is not a common practice. Continuous surveillance of animal and human data, both in terms of exposures and associated health outcomes, could provide valuable information to risk assessors and regulators. Using ortho-phthalates as case study, we asked whether RfDs deduced from male reproductive toxicity studies and set by traditional regulatory toxicology approaches sufficiently protect the population for o

SUBMITTER: Maffini MV 

PROVIDER: S-EPMC8591894 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature