Avoidance memory requires CaMKII activity to persist after recall.
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ABSTRACT:
SUBMITTER: Radiske A
PROVIDER: S-EPMC8591931 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
Avoidance memory requires CaMKII activity to persist after recall.
Radiske Andressa A Gonzalez Maria Carolina MC Rossato Janine I JI Apolinário Gênedy G de Oliveira João R JR Bevilaqua Lia R M LRM Cammarota Martín M
Molecular brain 20211114 1
Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessar ...[more]
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