Human dental pulp stem cells attenuate streptozotocin-induced parotid gland injury in rats.

ABSTRACT:

Objective

Diabetes mellitus causes deterioration in the body, including serious damage of the oral cavity related to salivary gland dysfunction, characterised by hyposalivation and xerostomia. Human dental pulp stem cells (hDPSCs) represent a promising therapy source, due to the easy, minimally invasive surgical access to these cells and their high proliferative capacity. It was previously reported that the trophic support mediated by these cells can rescue the functional and structural alterations of damaged salivary glands. However, potential differentiation and paracrine effects of hDPSCs in diabetic-induced parotid gland damage have not been investigated. Our study aimed to investigate the therapeutic effects of intravenous transplantation of hDPSCs on parotid gland injury in a

SUBMITTER: Al-Serwi RH 

PROVIDER: S-EPMC8591949 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature