Implementation of platform trials in the COVID-19 pandemic: A rapid review.

ABSTRACT:

Motivation

Platform designs - master protocols that allow for new treatment arms to be added over time - have gained considerable attention in recent years. Between 2001 and 2019, 16 platform trials were initiated globally. The COVID-19 pandemic seems to have provided a new motivation for these designs. We conducted a rapid review to quantify and describe platform trials used in COVID-19.

Methods

We cross-referenced PubMed, ClinicalTrials.gov, and the Cytel COVID-19 Clinical Trials Tracker to identify platform trials, defined by their stated ability to add future arms.

Results

We identified 58 COVID-19 platform trials globally registered between January 2020 and May 2021. According to trial registries, 16 trials have added new therapies (median 3, IQR 4) and 11 have d

SUBMITTER: Vanderbeek AM 

PROVIDER: S-EPMC8591985 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature