Antiretroviral Therapy in Children and Adolescents: A Look Into Modern Single Tablet Regimens.

ABSTRACT: Single tablet regimens (STRs) have simplified antiretroviral therapy (ART) over the years in the adult human immunodeficiency virus (HIV) population. However, there is still a prevalent need to simplify regimens in children and adolescents living with HIV. Finding the optimal regimen requires a multi-factorial approach due to their complex pharmacokinetic profiles throughout childhood and the challenges and limitations of medication non-adherence in the pediatric population. These challenges include pill size, available formulations, palatability, and caregiver health literacy, which can all affect the proper administration of medications. The complexity of this population implies the importance of customizing everyone's antiretroviral regimen so that the patient and family can successfull

SUBMITTER: Lee C 

PROVIDER: S-EPMC8591998 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature