Glyoxalase 1 Confers Susceptibility to Schizophrenia: From Genetic Variants to Phenotypes of Neural Function.

ABSTRACT: This research aimed to investigate the role of glyoxalase 1 (Glo-1) polymorphisms in the susceptibility of schizophrenia. Using the real-time polymerase chain reaction (PCR) and spectrophotometric assays technology, significant differences in Glo-1 messenger ribonucleic acid (mRNA) expression (P = 3.98 × 10^-5) and enzymatic activity (P = 1.40 × 10^-6) were found in peripheral blood of first-onset antipsychotic-naïve patients with schizophrenia and controls. The following receiver operating characteristic (ROC) curves analysis showed that Glo-1 could predict the schizophrenia risk (P = 4.75 × 10^-6 in mRNA, P = 1.43 × 10^-7 in enzymatic activity, respectively). To identify the genetic source of Glo-1 risk in schizophrenia,

SUBMITTER: Yin J 

PROVIDER: S-EPMC8592033 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature