The molecular clock gene cryptochrome 1 (CRY1) and its role in cluster headache.

ABSTRACT:

Background

Cluster headache is a severe primary headache disorder commonly featuring a strikingly distinct circadian attack pattern. Therefore, the circadian system has been suggested to play a crucial role in the pathophysiology of cluster headache. Cryptochromes are key components of the molecular clock generating circadian rhythms and have previously been shown to be associated with several psychiatric disorders, including seasonal affective disorder, bipolar disorder, and depression.

Methods

In this case-control study, we investigated the role of cryptochrome (CRY) genes in cluster headache by screening 628 cluster headache patients and 681 controls from Sweden for four known genetic variants in the CRY1 (rs2287161 and rs8192440) and CRY2 (rs10838524

SUBMITTER: Fourier C 

PROVIDER: S-EPMC8592106 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature