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Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants.

ABSTRACT: To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic background, and BV-3, an apparent recombinant lineage. This work highlights the potential of an undervaccinated younger population as a reservoir for the spread and generation of novel variants. This also demonstrates the value of whole genome sequencing as a routine disease surveillance tool.

SUBMITTER: Neuman BW 

PROVIDER: S-EPMC8592217 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants.

Neuman Benjamin W BW   Brashear Wesley A WA   Brun Marcel M   Chaki Sankar P SP   Fischer Rebecca S B RSB   Guidry Sierra J SJ   Hill Joshua E JE   Hillhouse Andrew E AE   Johnson Charles D CD   Kahl-McDonagh Melissa M MM   Metz Richard P RP   Rice-Ficht Allison C AC   Shuford Jennifer A JA   Skaggs Tiffany A TA   Stull Matthew A MA   Threadgill David W DW   Akpalu Yao Y   Zuelke Kurt K  

The American journal of tropical medicine and hygiene 20210920 5

To better understand the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant lineage distribution in a college campus population, we carried out viral genome surveillance over a 7-week period from January to March 2021. Among the sequences were three novel viral variants: BV-1 with a B.1.1.7/20I genetic background and an additional spike mutation Q493R, associated with a mild but longer-than-usual COVID-19 case in a college-age person, BV-2 with a T478K mutation on a 20B genetic  ...[more]

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