Magnetic Vortex Nanodiscs Enable Remote Magnetomechanical Neural Stimulation.

ABSTRACT: Magnetic nanomaterials in magnetic fields can serve as versatile transducers for remote interrogation of cell functions. In this study, we leveraged the transition from vortex to in-plane magnetization in iron oxide nanodiscs to modulate the activity of mechanosensory cells. When a vortex configuration of spins is present in magnetic nanomaterials, it enables rapid control over their magnetization direction and magnitude. The vortex configuration manifests in near zero net magnetic moment in the absence of a magnetic field, affording greater colloidal stability of magnetic nanomaterials in suspensions. Together, these properties invite the application of magnetic vortex particles as transducers of externally applied minimally invasive magnetic stimuli in biological systems. Using magnetic

SUBMITTER: Gregurec D 

PROVIDER: S-EPMC8592276 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature