Tissue Inhibitor of Metalloproteinase-1 Is Increased in Chagasic Cardiomyopathy.

ABSTRACT: Chagas disease (CD) mainly conveys stroke risk through structural cardiac disease. However, stroke and cognitive impairment are seen in CD independently of cardiac disease severity. Chronic inflammation may be an explanation for this association, because inflammation plays an important role in the pathogenesis of acute ischemic stroke and dementia. In the present study, we selected five candidate biomarkers for Chagas disease: interleukin-6, membrane metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP1), orosomucoid, and neprilysin. We sought to determine if mean levels of proinflammatory biomarkers are higher in patients with heart failure (HF) associated with Chagas disease when compared with other etiologies of HF. Patients were consecutively enrolled from subspecialty HF

SUBMITTER: Garcia KO 

PROVIDER: S-EPMC8592338 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature