First clinical expression of equine insect bite hypersensitivity is associated with co-sensitization to multiple Culicoides allergens.

ABSTRACT:

Background

Insect bite hypersensitivity (IBH) is an IgE-mediated allergic dermatitis in horses incited by salivary allergens from Culicoides spp. IBH does not occur in Iceland, as the causative agents are absent, however a high prevalence is seen in horses exported to Culicoides-rich environments.

Aims

To study the natural course of sensitization to Culicoides allergens and identify the primary sensitizing allergen(s) in horses exported from Iceland utilizing a comprehensive panel of Culicoides recombinant (r-) allergens.

Method

IgE microarray profiling to 27 Culicoides r-allergens was conducted on 110 serological samples from horses imported to Switzerland from Iceland that subsequently developed IBH or remained healthy. Furthermore, a longitudinal study of 31 IBH ho

SUBMITTER: Birras J 

PROVIDER: S-EPMC8592417 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature