MK2a inhibitor CMPD1 abrogates chikungunya virus infection by modulating actin remodeling pathway.

ABSTRACT: Chikungunya virus (CHIKV) epidemics around the world have created public health concern with the unavailability of effective drugs and vaccines. This emphasizes the need for molecular understanding of host-virus interactions for developing effective targeted antivirals. Microarray analysis was carried out using CHIKV strain (Prototype and Indian) infected Vero cells and two host isozymes, MAPK activated protein kinase 2 (MK2) and MAPK activated protein kinase 3 (MK3) were selected for further analysis. The substrate spectrum of both enzymes is indistinguishable and covers proteins involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling and transcriptional regulation. Gene silencing and drug treatment were p

SUBMITTER: Mamidi P 

PROVIDER: S-EPMC8592423 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature