Ketamine for critically ill patients with severe acute brain injury: Protocol for a systematic review with meta-analysis and Trial Sequential Analysis of randomised clinical trials.

ABSTRACT:

Introduction

Intensive care for patients with severe acute brain injury aims both to treat the immediate consequences of the injury and to prevent and treat secondary brain injury to ensure a good functional outcome. Sedation may be used to facilitate mechanical ventilation, for treating agitation, and for controlling intracranial pressure. Ketamine is an N-methyl-D-aspartate receptor antagonist with sedative, analgesic, and potentially neuroprotective properties. We describe a protocol for a systematic review of randomised clinical trials assessing the beneficial and harmful effects of ketamine for patients with severe acute brain injury.

Methods and analysis

We will systematically search international databases for randomised clinical trials, including CENTRAL, MEDLINE, Em

SUBMITTER: Madsen FA 

PROVIDER: S-EPMC8592463 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature